Increased robustness and speed in low-dose phase-contrast tomography with laboratory sources
نویسندگان
چکیده
In this article we discuss three different developments in Edge Illumination (EI) X-ray phase contrast imaging (XPCi), all ultimately aimed at optimising EI computed tomography (CT) for use in different environments, and for different applications. For the purpose of reducing scan times, two approaches are presented; the “reverse projection” acquisition scheme which allows a continuous rotation of the sample, and the “single image” retrieval algorithm, which requires only one frame for retrieval of the projected phase map. These are expected to lead to a substantial reduction of EI CT scan times, a prospect which is likely to promote the translation of EI into several applications, including clinical. The last development presented is the “modified local” phase retrieval. This retrieval algorithm is specifically designed to accurately retrieve sample properties (absorption, refraction, scattering) in cases where high-resolution scans are required in non-ideal environments. Experimental results, using both synchrotron radiation and laboratory sources, are shown for the various approaches.
منابع مشابه
Assessing the image quality and eye lens dose reduction using bismuth shielding in computed tomography of brain
Background: Epidemiological studies show that computed tomography (CT) is one of the main sources of ionizing radiations. Shielding of radiosensitive organs is one of the dose reduction methods. This study aimed to assess the eye lens dose reduction and image quality resulting from the use of radio-protective bismuth shield in brain CT imaging. Methods: Bismut...
متن کاملDiagnostic Performance and Safety of Positron Emission Tomography Using 18F-Fluciclovine in Patients with Clinically Suspected High- or Low-grade Gliomas: A Multicenter Phase IIb Trial
Objective(s): The study objective was to assess the diagnostic performance of positron emission tomography (PET) for gliomas using the novel tracer 18F-fluciclovine (anti-[18F]FACBC) and to evaluate the safety of this tracer in patients with clinically suspected gliomas.Methods: Anti-[18F]FACBC was administered to 40 patients with clinically suspected high- or low-grade gliomas, followed by PET...
متن کاملStrategies for fast and low-dose laboratory-based phase contrast tomography for microstructural scaffold analysis in tissue engineering
The application of x-ray phase contrast computed tomography (PCT) to the field of tissue engineering is discussed. Specific focus is on the edge illumination PCT method, which can be adapted to weakly coherent x-ray sources, permitting PCT imaging in standard (non-synchrotron) laboratory environments. The method was applied to a prominent research topic in tissue engineering, namely the develop...
متن کاملLow-dose phase contrast tomography with conventional x-ray sources.
PURPOSE The edge illumination (EI) x-ray phase contrast imaging (XPCi) method has been recently further developed to perform tomographic and, thus, volumetric imaging. In this paper, the first tomographic EI XPCi images acquired with a conventional x-ray source at dose levels below that used for preclinical small animal imaging are presented. METHODS Two test objects, a biological sample and ...
متن کاملInduction of DNA damage, apoptosis and micronuclei in peripheral blood lymphocytes following injection of contrast media in patients with abdominal CT scan
Background: Medical diagnostic procedures such as X-ray and computed Tomography (CT) scan account for considerable percent of patient's exposure to ionizing radiation. The exposure of cells to Ionization radiation results in induction of DNA damage and chromosomal aberrations. Contrast media (CM) are widely used in diagnostic radiology and CT scan. The aim of this study was to study adverse gen...
متن کامل